甲基汞的发育毒性及其研究进展

环境中的汞来源广泛,无机汞进入环境后可在微生物的作用下形成甲基汞。甲基汞是人类已知的致畸原,可以对生殖细胞造成损害,并进一步影响子代的生长发育。它极易通过胎盘屏障进入胎儿体内,影响子代的生长发育,改变子代与中枢神经系统功能有关的行为和认知能力。目前关于甲基汞发育毒性作用机理的研究也取得了一定的进展。

Progress in developmental toxicity of methylmercury

Mercury is a common pollutant in the environment and it can be turned into methylmercury (MeHg) under the metabolism of microbe. MeHg is a confirmed teratogen in human. It can impair the germ cells and influence the growth and development of the offspring. MeHg can easily pass through the placental barrier, accumulate in the fetus and change the behavior and perceptibility of the second generation related to the function of central nervous system. Recently, the investigations on the mechanism about developmental toxicity of MeHg have progressed much, so we make a review in this field as follows.