| 干扰素基因刺激因子激动剂的研究进展 |
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| 引用本文： | 杨倩,陈南南,尤启冬,徐晓莉. 干扰素基因刺激因子激动剂的研究进展[J]. 中国药科大学学报, 2022, 53(3): 253-263 |
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| 作者姓名： | 杨倩 陈南南 尤启冬 徐晓莉 |
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| 作者单位： | 国家知识产权局专利局专利审查协作北京中心，北京 100160,中国药科大学药物化学系，南京 211198,中国药科大学药物化学系，南京 211198,中国药科大学药物化学系，南京 211198 |
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| 基金项目： | 国家自然科学基金资助项目（No.82073692，No.82073766） |
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| 摘 要： | 干扰素基因刺激因子(STING)是机体自身免疫应答过程中的重要分子。鉴于STING被激活后可活化CD8~+T细胞的作用机制，STING激动剂与免疫检查点抑制剂的联合疗法具有良好的临床应用前景。本文对STING激动剂的结构类型、作用模式和结构修饰研究进展进行了总结，在此基础上对该类激动剂的研发趋势进行了展望，为后续研究提供了参考。
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| 关 键 词： | 干扰素基因刺激因子 激动剂 肿瘤免疫疗法 结构修饰 作用模式 进展 |
| 收稿时间： | 2021-10-12 |
| 修稿时间： | 2022-05-23 |
Research progress on stimulator of interferon genes (STING) agonists |
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| YANG Qian,CHEN Nannan,YOU Qidong and XU Xiaoli. Research progress on stimulator of interferon genes (STING) agonists[J]. Journal of China Pharmaceutical University, 2022, 53(3): 253-263 |
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| Authors: | YANG Qian CHEN Nannan YOU Qidong XU Xiaoli |
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| Affiliation: | Patent Examination Corporation Beijing Center of the Patent Office, China National Intellectual Property Administration, Beijing 100160,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | Stimulator of interferon genes (STING) is an important factor in the auto-immune response of our bodies.Considering the mechanism of activating CD8+ T cells after the activation of STING protein, the combination of STING agonists and immune checkpoint inhibitors for the treatment of tumor immunotherapy has good clinical application prospect.In this paper, the research progress of molecular types, mechanism of action and structural modifications of STING agonists were reviewed.The developing tendency were outlined to provide some references for further investigation. |
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| Keywords: | stimulator of interferon genes (STING) agonists tumor immunotherapy structural modifications mode of action advanceFoundation:This study was supported by the National Natural Science Foundation of China (No.82073692, No.82073766) |
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