亚胺培南/西司他丁致中枢神经系统不良反应的文献分析

目的 进一步了解亚胺培南/西司他丁中枢神经系统不良反应(ADR)的发生情况及危险因素,为临床合理用药提供参考.方法 检索中国知网(CNKI)、万方数据库(Wanfang)、中国生物医学文献数据库(CBM)及维普数据库(VIP)中亚胺培南/西司他丁致中枢神经系统ADR的病例报道,并进行统计分析.检索时间为自该药上市以来至...

Literature analysis of adverse drug reaction on central nervous system induced by imipenem/cilastatin

Objective To further comprehend the adverse drug reaction(ADR)on central nervous system induced by imipenem/cilastatin and the risk factors.Methods Case reports of ADR on central nervous system induced by imipenem/cilastatin were retrieved from CNKI,Wanfang,CBM,and VIP databases until May 1,2021,and the case reports were analyzed.Results A total of 86 references were included.One hundred and ten patients were enrolled in this study.They comprised 62 men(56.36%)and 48 women(43.64%)with an average age of(64.22±21.29).The average dose of 110 patients was(1.95±0.79)grams.Most primary diseases were respiratory infections.ADR induced by imipenem/cilastatin mostly occurred within 2-6 days after medication.The clinical manifestations in most patients were epileptic symptoms(58.18%)and conscious disturbance(35.46%).Conclusions Imipenem/cilastatin has some ADR on central nervous system.When patients accompanied by risk factors such as advanced age(over 60),renal insufficiency,inappropriate usage and dosage,or history of central nervous system diseases,the its clinical application should be cautious,and the ADR monitoring should be strengthened to ensure the safety of patients.