补虚生肌法对痔瘘术后创面愈合、炎症因子及疼痛介质的影响

目的:探讨补虚生肌法对促进痔瘘术后创面愈合程度、抗炎作用及疼痛介质的影响.方法:选择符合标准的病例200例,按随机数字表法分为治疗组与对照组各100例.两组患者均采取手术治疗,对照组术后给予康复新液纱条外敷,治疗组在此基础上给予内补黄芪汤优化方颗粒剂.比较两组治疗后创面愈合程度、炎症因子及疼痛介质等相关指标.结果:治疗...

Effect of Tonifying Deficiency and Generating Muscle on Wound Healing,Inflammatory Factors and Pain Mediators in Postoperative Hemorrhoid and Fistula

Objective:To explore the effect of tonifying deficiency and generating muscle on wound healing,anti-inflammation and pain mediators in postoperative hemorrhoid and fistula. Methods:Two hundred patients that meet the criteria were divided into treatment group and control group using a random number table,100 patients in each group. All patients underwent surgery. Patients after surgery in the control group were treated with external application of Kangfuxin liquid gauze and covered with medical dressing for fixation. Patients in the treatment group were given the Neibu Huangqi Youhua Formula（内补黄芪汤优化方 ） granules besides the treatment in the control group. The degree of wound healing,inflammatory factors and pain mediators were compared between two groups. Results:In the treatment group there were better total effective rate than those in the control group,with statistical difference(P<0.05). On the 3 rd,7 th and 14 th day after operation,there were significant differences between the treatment group and control group on the wound healing rate and the wound healing time(P<0.05). The visual analogue scale(VAS) scores of both groups on the 3 rd,7 th and 14 th day after operation were significantly lower than those on the 1 st day after operation,with statistical difference(P<0.05),and at each time point after operation the VAS scores of the treatment group were lower than these of the control group,with statistical difference(P<0.05). Levels of interleukin(IL)-1β,IL-12 and interferon(IFN)-γ showed no difference between both groups on the 1 st day after operation(P>0.05),and on the14 th day after operation,they became significantly lower in both groups,and in the treatment group were significantly lower than those in the control group(P<0.05). Levels of serum 5-hydroxytryptamine(HT),prostaglandin E2(PGE2),substance P(SP) and neuropeptide Y(NPY) showed no difference between both groups(P>0.05),but they became lower in both two groups on the 14 th day after operation than before operation,and they were lower in the treatment group than in the control group,both with statistical difference(P<0.05). Levels of epidermal growth factor(EGF),fibroblast growth factor(FGF)-1,secretory immunoglobulin A(sIgA) and tissue inhibitor of metalloproteinase(TIMP)-1 showed no statistical difference on the 1 st day after operation(P>0.05),but they became higher on the 14 th day after operation,and were higher in the treatment group than in the control group,both with statistical difference(P<0.05). Conclusions:Tonifying deficiency and generating muscle could improve the level of inflammatory factors and pain mediators,shorten the process of wound healing,relieving suffering of patients,effectively make up for the disadvantages of simple method of western medicine,and therefore improve the treatment effect.