不同他汀类药物的降脂作用及对冠心病患者炎症指标的疗效

目的:分析不同他汀类药物的降脂作用及对冠心病患者炎症指标的疗效。方法:选取2019年12月~2020年12月来某院开展治疗的冠心病患者66例作为观察对象,选择红蓝双色球法进行分组,分为对照组(阿托伐他汀钙片10mg)和实验组(辛伐他汀片40mg)各33例,对比分析两组的血脂水平、炎症指标,统计动脉粥样硬化程度与不良反应。结果:在甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)与高密度脂蛋白(HDL)水平上,实验组优于对照组(P<0.05)。在肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)以及基质金属蛋白酶-9(MMP-9)水平上,实验组低于对照组(P<0.05)。在颈动脉内-中膜厚度、冠状动脉狭窄程度评分以及颈动脉斑块积分上,实验组低于对照组(P<0.05)。在不良反应发生率上,实验组略低于对照组(P>0.05)。结论:相较于阿托伐他汀,辛伐他汀用于冠心病的治疗效果理想,对于血脂水平与炎症反应的改善具有促进作用,可有效减轻动脉粥样硬化程度,临床可进一步推广运用。

The Lipid-lowering Effects of Different Statins and Their Curative Effects on Inflammatory Indexes in Patients with Coronary Heart Disease

Objective:To analyze the lipid-lowering effects of different statins and their efficacy on in flammatory indicators in patients with coronary heart disease.Methods:A total of 66 observation subjects were included in this article,all of whom were patients with coronary heart disease treated in a hospital from December 2019 to December 2020.All patients were divided into control group(atorvastatin calcium tablets 10mg,n=33)and the experimental group(simvastatin tablets 40mg,n=33)by the red and blue two-color ball method.The blood lipid levels and inflammation indexes of the two groups were compared and analyzed,and the degree of atherosclerosis and adverse reactions were counted.Results:In terms of triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL)and high-density lipoprotein(HDL)levels,the experimental group was better than the control group(P<0.05).In tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)and matrix metalloproteinase-9(MMP-9)levels,the experimental group was lower than the control group(P<0.05).In carotid artery-media thickness,coronary artery stenosis score and carotid artery plaque score,the experimental group was lower than the control group(P<0.05).In the incidence of adverse reactions,the experimental group was slightly lower than the control group(P>0.05).Conclusion:Compared with atorvastatin,simvastatin has ideal therapeutic effect for coronary heart disease.It has promoting effect on the improvement of blood lipid levels and inflammation,and can effectively reduce the degree of atherosclerosis,which can be further promoted in clinical practice.