Paget病皮肤镜及反射式共聚焦显微镜特征分析

目的 探讨Paget病在偏振光皮肤镜(PD)及反射式共聚焦显微镜(RCM)下的特征.方法 选取2019年1月至2021年10月门诊就诊的29例Paget病患者76处皮损,对其临床资料、PD特征及RCM特征进行回顾性分析.结果 29例患者中男18例,女11例;其中乳房Paget病9例,乳房外Paget病20例.76处皮损...

Analyses of dermoscopic and reflectance confocal microscopic features of Paget disease

Objective To investigate polarized light dermoscopic and reflectance confocal microscopic features of Paget disease.MethodsDermoscopic and reflectance confocal microscopic features of 76 lesions were analyzed in 29 patients with Paget disease, who visited our clinic from January 2019 to October 2021. ResultsAmong the 29 patients, including 18 males and 16 females, 9 cases were mammary Paget disease and 20 cases were extramammary Paget disease, with a total of 76 lesions. Polarized light dermoscopy showed milky white structureless areas, bright white streaks, vascular structures and light brown to bluish gray dots in milky red and reddish brown background. Reflectance confocal microscopy examination of the lesions showed disorganized epidermal cells with vacuole like cells and Paget cells, formation of tumor nests by Paget cells in the basal layer, tortuous blood vessels in the superficial dermis with infiltrate of inflammatory cells, dendritic cells and pigmentophages. Dermoscopic and reflectance confocal microscopic features were similar in Paget and extramammary Paget diseases. ConclusionPaget disease displays specific characteristics under the polarized light dermoscope and reflectance confocal microscope, providing a basis for non invasive diagnosis of the disease.