自体外周血造血干细胞移植治疗恶性血液病的临床研究

目的：探讨自体外周血造血干细胞移植（ＡＢＳＣＴ）治疗恶性血液病的疗效。方法：ＡＢＳＣＴ１３例，自体外周血干细胞（ＰＢＳＣ）及自体骨髓联合移植１５例。移植前采用化疗加多抗甲素或粒细胞集落刺激因子（ＧＣＳＦ）动员外周血干细胞。结果：多抗甲素组每例采集单个核细胞数为（３．５８±２．１２）×１０８／ｋｇ，ＧＣＳＦ组为（６．６８±５．３１）×１０８／ｋｇ；接受移植的２８例患者中２１例呈持续缓解状态（ＣＣＲ），中位ＣＣＲ时间为１８（５～５８）个月，复发７例；３年无病生存率为６８．７％，复发率为２２．３％。结论：两种动员方案均有良好的动员效果；ＡＢＳＣＴ及ＰＢＳＣ和自体骨髓联合移植均具有良好疗效及造血功能恢复快、合并症少等优点，值得进一步推广应用。

Treatment of malignant hematological diseases with autologous peripheral blood stem cell transplantation

OBJECTIVE: To observe the effectiveness of autologous peripheral blood stem cell transplantation(ABSCT) in the treatment of malignant hematologic diseases. METHODS: Thirteen ABSCT and 15 autologous peripheral blood stem cells(ABSC) combining autologous bone marrow transplantation (ABMT) were performed for hematological malignancy patients. RESULTS: In polyactin A mobilization group, the mononuclear cells(MNC) collected in each case were 3.58 +/- 2.12 x 10(8)/kg, and in G-CSF mobilization group 6.68 +/- 5.31 x 10(8)/kg. Twenty-one of the 28 transplanted cases achieved continuous complete remission(CCR). The medium CCR duration was 18(5-58) month. The 3 year disease-free survival rate was 68.7% and relapse rate was 22.3%. CONCLUSION: After ABSCT or ABSC combining ABMT, there were earlier hematopoietic reconstitution and fewer complications than that after ABMT.