| 氮酮对消痤乳膏中克林霉素和螺内酯透皮吸收作用的研究 |
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| 引用本文： | 曾明辉,何林,孙世明,谭正怀.氮酮对消痤乳膏中克林霉素和螺内酯透皮吸收作用的研究[J].中国药事,2004,18(2):102-104. |
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| 作者姓名： | 曾明辉 何林 孙世明 谭正怀 |
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| 作者单位： | 1. 四川省人民医院药剂科,成都,610072
2. 四川省中药研究所 |
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| 摘 要： | 研究不同浓度的氮酮对盐酸克林霉素和螺内酯小鼠离体皮肤渗透性的影响.用改良的Franze扩散池,选用不同浓度氮酮(0%、1%、2%和5%)作促渗剂,采用HPLC法测定药物累积释放量(Q),并计算稳态流量(J),渗透系数(Kp).结果表明1%氮酮对消痤乳膏的透皮吸收作用明显.
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| 关 键 词： | 氮酮 盐酸克林霉素 螺内酯 透皮吸收 |
| 文章编号： | 1002-7777(2004)02-0102-03 |
Effects of Azone on the Percutaneous Absorption of Clindamycin Hydrochloride and Spironolactone in Acne Treatment Cream |
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| Zeng Minghui,He Lin,Sun Shiming and Tan Zhenghuai.Effects of Azone on the Percutaneous Absorption of Clindamycin Hydrochloride and Spironolactone in Acne Treatment Cream[J].Chinese Pharmaceutical Affairs,2004,18(2):102-104. |
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| Authors: | Zeng Minghui He Lin Sun Shiming and Tan Zhenghuai |
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| Institution: | Zeng Minghui,He Lin,Sun Shiming and Tan Zhenghuai1 |
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| Abstract: | The effects of azone of different concentration on the in vitro percutaneous absorption of Clindamycin hydrochloride and Spironolactone were studied with Mice skin. Accumulated permeation quantity (Q) was determined by HPLC with improved Franze diffusing cell. Azone of different concentration were used as permeation accelerants. Steady percutaneous flow (J) and permeation coefficient were calculated. The results showed that azone significantly increased the cream's permeation. |
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| Keywords: | Azone clindamycin hydrochloride spironolactone percutaneous absorption |
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