比索洛尔联合单硝酸异山梨酯缓释片治疗频发室性早搏的疗效

目的观察比索洛尔联合单硝酸异山梨酯缓释片治疗频发室性期前收缩的临床疗效。方法将104例频发室性期前收缩且伴有心悸症状的患者按随机数字表法分为对照组和观察组,每组52例。对照组给予比索洛尔2.5 mg,口服,1次·d-1,逐步增加到负荷剂量,最高10 mg·d-1;观察组在对照组药物治疗的基础上,给予单硝酸异山梨酯缓释片30 mg,口服,1次·d-1。2组均4周为1个疗程。2组患者于治疗前后均进行动态心电图检查,记录治疗后24 h期前收缩总数量并观察疗效,跟踪出院3个月后因心律失常再次入院的情况。结果观察组总有效率及出院后3个月再入院率分别为92.3%及15.4%,对照组总有效率及出院后3个月再入院率分别为69.2%及32.7%,2组比较差异均有统计学意义(均P<0.05)。2组患者服药期间均未发现明显不良反应。结论比索洛尔联合单硝酸异山梨酯缓释片治疗频发室性期前收缩临床疗效明显优于单用比索洛尔,且不良反应少、安全性好。更多还原

Clinical Efficacy of Bisoprolol Combined with Isosorbide Mononitrate Sustained Release Tablets in Frequent Premature Ventricular Contractions

Objective To observe the clinical efficacy of bisoprolol combined isosorbide mononitrate sustained release tablets in the treatment of frequent premature ventricular contractions. Methods A total of 104 patients with frequent premature ventricular contractions and palpitations were randomly divided into two groups, with 52 patients in each group. The control group was orally given bisoprolol 2.5 mg once per day （the loading dose was increased gradually and the maximum dose was 10 mg·d -1）.On the basis of bisoprolol treatment,the observation group was orally given isosorbide mononitrate sustained release tablets 30 mg once per day. The duration of a treatment was 4 weeks. Dynamic electrocardiography was performed before and after treatment,and premature ventricular contractions within 24 hours after treatment were recorded. The rate of readmission due to arrhythmia was followed-up 3 months after discharge from the hospital. Results The total effective rate and readmission rate were,respectively,92.3% and 15.4% in observation group, and 69.2% and 32.7% in control group.The differences were statistically significant between the two groups（P〈0.05）. Conclusion The combined treatment with bisoprolol and isosorbide mononitrate sustained release tablets has better efficacy and safety and leads to fewer adverse reactions than bisoprolol alone for frequent premature ventricular contractions.