内脏脂肪素与冠心病的相关性研究

目的探讨内脏脂肪素(Visfatin)与冠心病的关系及手术前后浓度的变化。方法将100例疑诊冠心病行冠状动脉手术治疗的患者根据冠状动脉造影检查结果,分为急性冠状动脉综合征组(ACS组,40例)、稳定性心绞痛组(SAP组,30例)及冠状动脉造影正常组(对照组,30例)。采用酶联免疫法(ELISA法)检测各组术前及冠心病组术后血清Visfatin水平;室验室检测各组肾功能、血糖及血脂等生化指标。结果各组在年龄、性别、体质指数、高血压、糖尿病、吸烟、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、Cr及BUN等方面比较差异均无统计学意义(均P>0.05)。术前ACS组血清Visfatin为(67.81±4.15)μg·L-1,SAP组为(47.37±2.54)μg·L-1,对照组为(28.02±1.09)μg·L-1,ACS组及SAP组均明显高于对照组、ACS组高于SAP组(均P<0.05)。ACS组及SAP组术后24 h血清Visfatin水平均较术前明显升高(76.34±3.69)、(51.9±3.60)μg·L-1,均P<0.05)。结论血清Visfatin在冠心病患者外周血中浓度的升高提示冠状动脉粥样斑块的不稳定性,可能成为预测人类冠心病及冠状动脉病变程度的有用指标,对冠心病的早期诊治、判断病变程度及指导早期行有创检查均有重要的参考价值。

Relationship between Visfatin and Coronary Heart Disease

Objective To investigate the correlation between visfatin and coronary heart disease （CHD）, and to observe the changes in Visfatin concentrations after percutaneous coronary intervention （PCI）. Methods According to the results from coronary angiography,100 patients were divided into three groups：acute coronary syndrome group（ACS group,n=40）,stable angina pectoris group（SAP group, n=30）and normal coronary angiography group （control group,n=30）.Serum levels of visfatin were measured by ELISA before and after operation. Furthermore, renal function,blood glucose,blood lipid, and other indexes were determined. Results There were no significant differences in the age,gender, body mass index,hypertension,diabetes,smoking,total cholesterol （TC）,triglyceride （TG）,low-density lipoprotein, creatinine and blood urea nitrogen（BUN）among the three groups（P＆gt;0.05）.Before operation, serum visfatin levels were（67.81±4.15）μg·L-1,（47.37±2.54）μg·L-1 and （28.02±1.09） μg·L-1 in ACS group, SAP group and control group, respectively. The differences in visfatin levels were significant among the three groups （P＆lt;0.05）.Compared with preoperative levels,serum Visfatin levels significantly increased after operation in both ACS group and SAP group （76.34±3.69）、（51.9±3.60）μg·L-1,all P＆lt;0.05]. Conclusion The increase in serum Visfatin levels can imply the instability of coronary atherosclerotic plaques. Therefore, the Visfatin can be used as an index for predicting human CDH and the extent of coronary artery disease. The determination of serum Visfatin levels has an important reference value for early diagnosis,judgment of lesion degree and guidance and early invasive inspection in CHD.