垂体后叶素联合奥曲肽治疗肝硬化并上消化道出血的疗效

目的 探讨垂体后叶素联合奥曲肽治疗肝硬化并上消化道出血的临床疗效和安全性.方法 将70例肝硬化并上消化道出血患者按人院的先后顺序分为观察组和对照组,每组35例.2组均采用常规治疗,并采用蛇毒血凝酶治疗.在此基础上,对照组采用去甲肾上腺素联合奥美拉唑治疗,观察组采用垂体后叶素联合醋酸奥曲肽注射液治疗.观察2组治疗后出血时间、临床疗效及不良反应的情况.结果 观察组总有效率明显高于对照组（100.0％比80.0％,P＜0.05）,观察组治疗后出血时间为（20.76±2.87）h,明显短于对照组的（32.09±2.90）h,（P＜0.05）.结论 垂体后叶素联合奥曲肽治疗肝硬化并上消化道出血疗效显著,可作为肝硬化并上消化道出血的有效治疗措施之一.

Effects of Pituitrin Combined with Octreotide on Liver Cirrhosis Complicated by Upper Gastrointestinal Bleeding

Objective To investigate the clinical efficacy and safety of combined treatment with pituitrin and octreotide in patients with liver cirrhosis and upper gastrointestinal hemo Seventy patients with liver cirrhosis and upper gastrointestinal hemorrhage were group and control group according to the order of admission ,with 35 patients in divided into observation each group. All patients received conventional therapy and hemocoagulase treatment. In addition,the control group was given noradrenaline and omeprazole,and the observation group was given pituitrin and octreotide. Bleeding time, curative effects and adverse reactions were control group,combined treatment with pituitrin （100.0% vs 80.0% ;P〈0.05）,and shortened the bl observed in both groups. Results Compared with and octreotide increased the total effective rate eeding time （20.76±2.87）hours vs （32.09±2.90） hours;P〈0.05].Conclusion The pituitrin combined with octreotide can be used as an effective treatment for liver cirrhosis complicated by upper gastrointestinal bleeding.