| 抗肿瘤药曲磷胺的合成工艺改进 |
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| 引用本文： | 杨伟强,李雪健,毛侦军.抗肿瘤药曲磷胺的合成工艺改进[J].海峡药学,2010,22(7):230-232. |
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| 作者姓名： | 杨伟强 李雪健 毛侦军 |
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| 作者单位： | 1. 浙江海正药业股份有限公司,台州,318000
2. 浙江大学化学系,杭州,310027 |
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| 摘 要： | 目的对曲磷胺的合成工艺改进。使之适合工业化生产。方法以二乙醇胺、乙醇胺和3-氧丙醇为起姑原料经磷酰氯化、环磷酰胺化等关键步骤合成曲磷胺。结果与结论合成经工艺改进。多步收率有较大提高．总收率为41％。
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| 关 键 词： | 化学合成 工艺改进 曲磷胺 |
Synthesis improvement of antitumor agent trofosfamide |
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| YANG Wei-qiang,LI Xue-jian,MAO Zhen-jun.Synthesis improvement of antitumor agent trofosfamide[J].Strait Pharmaceutical Journal,2010,22(7):230-232. |
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| Authors: | YANG Wei-qiang LI Xue-jian MAO Zhen-jun |
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| Institution: | YANG Wei-qiang, LI Xue-jian, MAC Zhen-jun( 1. Zhejiang Haizheng Pharmaceutical CO Ltd., Taizhou 318000, China; 2. Department of Chemistry, Zhejiang University, Hangzhou 310027, China) |
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| Abstract: | OBJECTIVE To improve synthesis technics of trofosfamide and adapt it to industrialized production. METHOD It was synthesized from Diethanolamine, ethanolamine, and 3-chloro-propyl alcohol via Phosphoryl-chlorination, Cyclicphosphoryl-amination. RESULTS and CONCLUSION Some reaction conditions had been improved and the total yield raised to 41% by using the cheaper reagents. |
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| Keywords: | Chemical synthesis Technics improvement Trofosfamide |
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