A better cell cycle target for gene therapy of colorectal cancer: Cyclin G |
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Authors: | Rodrigo?Perez Nancy?Wu Adam?A?Klipfel JrEmail author" target="_blank">Robert?W?BeartJrEmail author |
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Institution: | (1) Division of Coloproctology, University of Sao Paulo School of Medicine, Sao Paolo, Brazil;(2) Department of Pathology, Keck School of Medicine, University of Southern California, LosAngeles, California;(3) Division of Colorectal Surgery, Keck School of Medicine, University of Southern California, LosAngeles, California;(4) Keck School of Medicine, University of Southern California, 1450 San Pablo St., Suite 5400, 90033 Los Angeles, CA |
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Abstract: | The purpose of this study was to evaluate the overexpression of cyclin G in colorectal neoplasia, which may be a more frequent
event than cyclin D1 during the cell cycle and thus may have a more enhanced therapeutic potential in treating colorectal
cancer. Ninety formalin-fixed, paraffin-embedded human colon and rectal specimens were obtained from the Pathology Department
of Norris Cancer Center/ University of Southern California. The tissues had been obtained after surgical resection between
1995 and 2001, and had been processed by routine clinical histopathologic methods. Ninety-one percent of colorectal tumors
had cyclin G overexpression. These cyclin-positive patients were evenly distributed between men and women, and between tumor
locations, that is, 36% rectal tumors and 34% rightsided tumors. Thirty-two percent were well differentiated, and 66% were
moderately differentiated. Thirty patients (38%) had stage I disease, 16 (20%) had stage II disease, 25 (32%) had stage III,
and seven (9%) had stage IV disease. Eight patients (10%) in this group had recurrent disease during follow-up. There was
no correlation between cyclin G overexpression and clinical and pathologic characteristics. Cyclin D1 overexpression was found
to be present in only 42% of colorectal adenocarcinomas. There was no correlation between cyclin D1 overexpression and clinical
and pathologic characteristics. The present study demonstrates that cyclin G overexpression is a frequent event in colorectal
cancer. This frequent event in colorectal carcinogenesis may facilitate new therapeutic approaches acting as a target for
gene therapy, possibly directed at downregulating cyclin G in colorectal cancer.
Presented at the Forty-Fourth Annual Meeting of The Society for Surgery of the Alimentary Tract, Orlando, Florida, May 18-21,
2003 (poster presentation). |
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Keywords: | Colon cancer cancer epidemiology |
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