氟非尼酮抗器官纤维化的作用及机制

器官纤维化可发生于不同的组织器官，其发病率高、危害性大，尚缺乏有效的治疗药物。近年发现的新 型抗纤维化小分子化合物--氟非尼酮，为纤维化疾病的治疗带来了希望。氟非尼酮可以通过抗炎症反应、抗氧化 应激、抗细胞凋亡、抑制肌成纤维细胞的活化与增殖、促进细胞外基质降解及调节信号转导等多种途径，起到抗器 官纤维化的作用，明显减轻肾、肝及肺的纤维化程度。

Effect and mechanism of fluorofenidone on organ fibrosis

Fibrosis can occur in diff erent organs with high incidence rate and great danger. It still lacks eff ective drugs for prevention of fi brosis. Fluorofenidone is a newly developed drug with anti-fi brotic activity, which provides a new hope for treating the progressive fi brotic diseases. Recent studies have shown that fl uorofenidone is a multifunctional small molecule with anti-infl ammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofi broblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can be applied to att enuate the progression of renal, hepatic and pulmonary fi brosis.