山东省人巨细胞病毒感染的流行病学调查及其相关因素研究

目的：了解山东省人巨细胞病毒（human cytomegalovirus，HCMV）感染情况及其相关影响因素。方法：在山东省随机选取1870例研究对象，利用ELISA方法进行HCMV IgM、IgG检测，并进行血型、SDF1和CCR2受体基因的多态性检测。对HCMV IgM和IgG阳性率进行分析，研究其与地区、性别、职业、年龄、血型以及SDF1和CCR2受体基因多态性的关系。结果：山东省HCMV IgM阳性率为40.21％，IgG阳性率为48.07％；各地区IgM和IgG有显著差异（P ＜ 0.05）；女性IgM和IgG显著高于男性；农民和医生IgG显著高于其他职业人群；随年龄增加，IgG阳性率增加；HCMV感染与血型、SDF1和CCR2受体多态性无显著性关联。结论：山东省HCMV现行感染率较高，与地区、性别、职业、年龄等因素相关。与血型、SDF1和CCR2受体多态性无关。

Epidemiological study of HCMV and its related factors in Shandong Province

Objective: To explore the infection rate of human cytomegal ovirus(HCMV) and its related factors in Shandong Province. Methods: HCMV IgM and IgG of 1870 blood samples from Shandong Province were detected using ELISA method, and blood type, SDF1 receptor and CCR2 receptor gene polymorphisms were also detected. Excel and SAS softwares were used to study HCMV IgM and IgG positivity rates and their relationships with sex, age, work, blood type, SDF1 receptor and CCR2 receptor gene polymorphisms. Results: The positivity rates of HCMV IgM and IgG in Shandong Province were 40.21% and 48.07% respectively. There were significant differences of IgM and IgG among districts. The positivity rates of IgM and IgG for female were higher than those for male. The positivity rates of IgG in peasants and doctors were higher than in other employees, and increased with age in all persons. There were no significant associations of HCMV with blood types, SDF1 receptor and CCR2 receptor gene polymorphisms. Conclusion: The HCMV positivity rate at present is high, and is correlated with geography, sex, work and age, but not with blood type, SDF1 receptor and CCR2 receptor gene polymorphisms.