| 复方环丙沙星栓剂的制备及其含量测定 |
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| 引用本文： | 姜赛平,陈建,卢晓阳,叶轶青.复方环丙沙星栓剂的制备及其含量测定[J].中国现代应用药学,2008,25(4):350-352. |
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| 作者姓名： | 姜赛平 陈建 卢晓阳 叶轶青 |
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| 摘 要： | 目的 制备环丙沙星-奥硝唑复方栓剂并建立其含量测定方法.方法 以PEG400,PEG6000为基质,熔融法制备环丙沙星-奥硝唑复方栓剂,采用高效液相色谱法进行含量测定.结果 制备得到水溶性基质的环丙沙星-奥硝唑复方栓剂;环丙沙星在41.6～416 μg·mL-1浓度范围内线性关系良好(r=0.999 1),平均回收率为(98.45±0.51%)%;奥硝唑在43～430 μg·mL-1浓度范围内线性关系良好(r=0.999 6),平均回收率为(98.70±0.49)%.结论 该制备工艺简单,含量测定方法操作简便,测定结果准确可靠,可用于复方环丙沙星栓剂的质量控制.
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| 关 键 词： | 环丙沙星 奥硝唑 栓剂 高效液相色谱法 |
Preparation and Determination of Compound Ciprofloxacin Suppository |
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| JIANG Sai-ping,CHEN Jian,LU Xiao-yang YE Yi-qing.Preparation and Determination of Compound Ciprofloxacin Suppository[J].The Chinese Journal of Modern Applied Pharmacy,2008,25(4):350-352. |
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| Authors: | JIANG Sai-ping CHEN Jian LU Xiao-yang YE Yi-qing |
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| Abstract: | OBJECTIVE To prepare ciprofloxacin-ornidazole suppository and establish an HPLC method for content determination.METHODS PEG 400 and PEG6000 were used as suppository base and the drug concentration was determined by HPLC. RESULTS The suppository was prepa |
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| Keywords: | ciprofloxacin ornidazole suppository HPLC |
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