| 黏着斑激酶与肿瘤 |
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| 引用本文： | 胡章颜,刘文庆,刘康达. 黏着斑激酶与肿瘤[J]. 基础医学与临床, 2007, 27(10): 1177-1180 |
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| 作者姓名： | 胡章颜 刘文庆 刘康达 |
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| 作者单位： | 绍兴文理学院,医学院,基础医学部,浙江,绍兴,312000;复旦大学,中山医院,实验研究中心,上海,200032 |
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| 摘 要： | 黏着斑激酶是一种非受体酪氨酸激酶,通过多种信号途径在细胞周期调控、生长调节、黏附、细胞骨架组装、运动、生存等方面发挥重要作用。研究发现,黏着斑激酶在多种肿瘤中高表达,参与肿瘤的发生、发展、侵袭、转移等。黏着斑激酶已成为当前肿瘤研究热点,有可能成为肿瘤治疗的新靶点。
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| 关 键 词： | 黏着斑激酶 信号传导 肿瘤 治疗 |
| 文章编号： | 1001-6325（2007）10-1177-04 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006-12-01 |
Focal adhesion kinase and cancer |
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| HU Zhang-yan,LIU Wen-qing,LIU kang-da. Focal adhesion kinase and cancer[J]. Basic Medical Sciences and Clinics, 2007, 27(10): 1177-1180 |
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| Authors: | HU Zhang-yan LIU Wen-qing LIU kang-da |
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| Affiliation: | 1. Medical Collage of Shaoxing University, Shaoxing 312000 ; 2. Fudan University Zhongshan Hospital, Shanghai 200032, China |
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| Abstract: | Focal adhesion kinase(FAK),the non-receptor tyrosine kinase,has been implicated in regulating a number of fundamental biological signal transudation pathways that control cell proliferation,survival,adhesion,motility.Many researches have reported that FAK highly expressed in many cancers and involved in the process of cancer development,such as initial,progress,metastasis,multi-drug resistance of cancer.FAK has been the hotpot in cancer research,and it will be a new target in cancer therapy. |
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| Keywords: | FAK signal conduction cancer therapy |
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