国内盐酸哌甲酯控释片治疗儿童注意缺陷多动障碍的Meta分析

目的应用Meta分析评价国内盐酸哌甲酯控释片(专注达)与传统药物治疗18岁以下儿童注意缺陷多动障碍(ADHD)的临床疗效。方法通过中国学术期刊网全文数据库(CNKI,1979-2008)、中国生物医学文献数据库(CBMdisc,1978-2008)和国家科技图书文献中心等,检索国内有关盐酸哌甲酯控释片治疗儿童ADHD的随机临床对照试验,由两位评价者进行质量评价,并对符合纳入标准的临床试验研究进行Meta分析。结果共查阅到国内相关临床研究13篇,最终进入评价的临床研究4篇,患儿174例。合并分析表明,盐酸哌甲酯控释片与传统治疗药物比较,可显著降低患儿ADHD-RS量表的评分(P<0.01),平均减分值之差(95%CI)为-7.85(-9.07,-6.64)]。结论从现有的临床证据看,盐酸哌甲酯控释片在改善18岁以下ADHD患儿的核心症状方面疗效显著。但由于样本数较少,该药与传统治疗药物的疗效对比仍需大规模、高质量、随访结局统一的临床试验进一步验证。

Meta-analysis of methylphenidate hydrochloride controlled release tablets on attention deficit hyperactivity disorder(ADHD)of children in China

Objective To assess the efficacy of methylphenidate hydrochloride controlled release tablets in treatment of attention deficit hyperactivity disorder(ADHD) of children by Meta analysis.Methods According to the requirements of cochrane systematic review,a thorough literature search was performed among Chinese Digital Hospital Library(www.chkd.Cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).Quality assessments of clinical trials were carried out.Randomized controlled trials(RCTs) with meth...