Binding of [3H]cimetidine to rat brain tissue |
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| Authors: | Ian R Smith Mark T Cleverley C Robin Ganellin Kathleen M Metters |
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| Institution: | (1) Research Institute, Smith Kline and French Research Ltd., AL7 1EY Welwyn Garden City, Herts, UK |
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| Abstract: | Binding of 3H]cimetidine to rat brain tissue was investigated, and a saturable binding with dissociation constant 0.22±0.05  M found. This binding is inhibited by a range of imidazole-derived histamine H2-receptor antagonists, but not by a number of non-imidazole H2-receptor antagonists. It is concluded that the 3H]cimetidine binding site in rat brain tissue that is labelled in these experiments is not the histamine H2-receptor. |
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