Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals |
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| Authors: | R J Broersma L W Kutcher E F Heminger J L Krstenansky F N Marshall |
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| Affiliation: | Merrell Dow Research Institute, Indianapolis, IN. |
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| Abstract: | A synthetic hirudin55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused dose-related inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism in mice and inhibition of stasis-induced venous thrombosis in rats. Antithrombotic effectiveness corresponded with anticoagulant activity. Anephric animals exhibited longer duration of activity than normal animals suggesting the kidney as a major route of elimination. |
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