Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression |
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| Authors: | Roman A Blaheta Frederick H Daher Martin Michaelis Christoph Hasenberg Eva M Weich Dietger Jonas Rouslan Kotchetkov Hans Willhelm Doerr Jindrich Cinatl |
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| Affiliation: | (1) Zentrum der Chirurgie, Klinik f?r Urologie und Kinderurologie; Johann Wolfgang Goethe-Universit?t, Frankfurt am Main, Germany;(2) Zentrum der Hygiene, Institut f?r Medizinische Virologie; Johann Wolfgang Goethe-Universit?t, Frankfurt am Main, Germany |
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| Abstract: | Background Drug resistance to chemotherapy is often associated with increased malignancy in neuroblastoma (NB). One explanation for the link between resistance and malignancy might be that resistance facilitates cancer progression and invasion. To investigate this hypothesis, adhesion, transendothelial penetration and NCAM (CD56) adhesion receptor expression of drug-resistant versus drug-sensitive NB tumor cells were evaluated. |
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