Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat |
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| Authors: | Noel N Kim Miljan Stankovic Abdullah Armagan Tulay T Cushman Irwin Goldstein Abdulmaged M Traish |
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| Affiliation: | (1) Department of Urology, Institute for Sexual Medicine, Boston University School of Medicine, Boston, Massachusetts, USA;(2) Department of Urology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey;(3) Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA;(4) Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA |
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| Abstract: | Background Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with sexual side effects, such as increased vaginal dryness and pain/discomfort during sexual activity. There have been limited investigations of the effect of tamoxifen on estrogen-dependent peripheral genital arousal responses. The objective of this study was to investigate the effects of tamoxifen on vaginal physiology in the rat. |
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