Gene expression patterns associated with p53 status in breast cancer |
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| Authors: | Melissa A Troester Jason I Herschkowitz Daniel S Oh Xiaping He Katherine A Hoadley Claire S Barbier Charles M Perou |
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| Affiliation: | (1) Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA;(2) Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;(3) Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;(4) Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;(5) Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA |
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| Abstract: | Background Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation status is tightly linked to other characteristics of prognostic importance, it is difficult to identify p53's independent prognostic effects. The relation between p53 status and subtype can be better studied by combining data from primary tumors with data from isogenic cell line pairs (with and without p53 function). |
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