Morphine stimulates CCL2 production by human neurons |
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| Authors: | R Bryan Rock Shuxian Hu Wen S Sheng Phillip K Peterson |
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| Institution: | (1) Center for Infectious Diseases and Microbiology Translational Research and the Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA;(2) Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, McGuire Translational Research Facility, 2001 6th Street SE #3-218, Minneapolis, MN 55455, USA |
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| Abstract: | Background Substances of abuse, such as opiates, have a variety of immunomodulatory properties that may influence both neuroinflammatory
and neurodegenerative disease processes. The chemokine CCL2, which plays a pivotal role in the recruitment of inflammatory
cells in the nervous system, is one of only a few chemokines produced by neurons. We hypothesized that morphine may alter
expression of CCL2 by human neurons. |
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