C(3)-cyclopropyl cephems and carbacephems |
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| Authors: | D O Spry N J Snyder J S Kasher |
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| Affiliation: | Lilly Research Laboratory, Eli Lilly & Company, Indianapolis, Indiana 46285. |
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| Abstract: | A series of C(3)-cyclopropyl cephems and carbacephems has been prepared by palladium catalyzed addition of diazomethane to the corresponding C(3)-vinyl derivatives. The phenylglycyl cyclopropyl cephem derivatives exhibit better Gram-positive activity than cephalexin or cefaclor, while the aminothiazole oxime cyclopropyl cephem derivatives were not as active as the corresponding C(3)-vinyl cephems. |
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