多沙唑嗪治疗高血压病的疗效观察

目的：评价多沙唑嗪的降压疗效和安全性。方法：４１例高血压病人随机分成二组。试验组Ａ（服多沙唑嗪），对照组Ｂ（服特拉唑嗪），进行为期４周的治疗观察。结果：Ａ组总有效率８６％。服药４周后平均收缩压（ＳＢＰ）和舒张压（ＤＢＰ）分别下降了１５．５ｍｍＨｇ和１２．８ｍｍＨｇ，Ｂ组总有效率８５％，ＳＢＰ和ＤＢＰ下降的幅度为１２４．０ｍｍＨｇ和１３．０ｍｍＨｇ。两组总有效率无显著性差异。结论：多沙唑嗪是一种安全有效的抗高血压药物。

The efficiency of doxazosin in patients with essential hypertension

OBJECTIVE:To estimate the efficiency and safety of doxazosin. METHODS:Forty one cases with essential hypertension were divided randomly into two groups: trial A (used doxazosin) and control B (used terazosin). Treatment lasted for 4 weeks. RESULTS:Total effective rate was 86% in A group and 85% in B group. SBP and DBP reductions in A group were 15 5mmHg and 12 8mmHg and in B group 14 0mmHg and 13 0mmHg. There was no significant difference in total effective rate between the two groups. CONCLUSION:Doxazosin is effective and well tolerated in treating hypertensive patients.