高脂血症患者血液流变学、血小板聚集的探讨

本文对420例高脂血症患者进行血液流变学和血小板聚集功能的测定。结果表明,老年前期和老年期的高脂血症患者,全血粘度、血浆粘度、红细胞压积、血沉、血沉方程K值、红细胞电泳、纤维蛋白原、血小板最大聚集率和5分钟解聚率与血脂正常者比较,除红细胞压积差异显著(P<0.05)外,其余差异均为极显著(P<0.01);青中年高脂血症患者与血脂正常者比较,低切变全血粘度、红细胞电泳、血小板最大聚集率差异显著(P<0.01)。说明高脂血症造成血液高粘、高凝、高聚状态,尤其是高血脂老年,血液流变学、血小板聚集的指标改变更为严重。

Study on Hemorrheologic Changes and Platelet Aggregation in Hyperlipidemia Patients

The hemorrheologic parameters and platelet aggregation in 420 cases of hyperlipidemia patients were determined. The whole blood viscosity, plasma viscosity, hematocrit, erythrocyte sedimentation rate (ESR), K value of ESR equation, erythrocyte eletrophoresis, fibrinogen, the largest platelet aggregation rate and 5 minute platelet deaggregation rate in pre-senile and senile patients with hyperlipidemia were compared with those normal. The results showed that, not only the hematocrit was significantly different(P <0.05), but also the other indices were significantly different (P<0.01) between normal and abnormal groups. Moreover, the low shear rate whole blood viscosity, erythrocyte electrophoresis and the largest platelet aggregation rate in young and middle age patients with hyperlipidemia were signifcantly different from those normal (P<0. 01). These results indicated that the hyperlipidemia brings about the state of hepervis-cosity, hypercoagulability and hyperaggregation, especially in senile hyperlipidemia subjects the changes of the hemorrheological indices and platelet aggregation are more serious.