维持性血液透析患者血液标志物的临床意义

目的 探讨维持性血液透析(MHD)患者血液标志物对心血管疾病预测的临床意义.方法 维持性血液透析患者分心血管疾病组27例和对照组36例,检测血纤维蛋白原(Fib)、D-二聚体(D-D)、血管性假血友病因子(vWF)、C-反应蛋白(CRP)、甘油三酯(TG)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)和血清白蛋白(ALB)水平.结果 心血管疾病组患者纤维蛋白原、D-二聚体、血管性假血友病因子、CRP均增高,与对照组相比差异均有显著性(P<0.05);心血管疾病组患者血清白蛋白降低,与对照组相比差异有显著性(P<0.05);心血管疾病组患者甘油三酯、血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇与对照组相比差异均无显著性(P>0.05).结论 MHD者发生心血管疾病并发症与血纤维蛋白原、D-二聚体、血管性假血友病因子、C-反应蛋白、血清白蛋白有一定的关系.

Clinical Significance of Blood Markers of MHD Patients

Objective To explore the clinical significance of blood markers of MHD(maitenance hemedialyses) patients to the prediction of cardiovascular disease(CVD). Methods MHD patients were divided into CVD group with 27 cases(group A) and non-CVD group with 36 cases(group B).Fib,D-D,vWF,CRP,TG,TC,HDLC,LDLC,ALB of blood were measured.Result Fib,D-D,vWF,CRP of group A were increased compared with group B,and the difference was significant(P<0.05);ALB of group A were decreased compared with group B with obvious differ...