Acute toxoplasma myositis: an immunohistochemical and ultrastructural study |
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| Authors: | S Matsubara M Takamori H Adachi H Kida |
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| Institution: | (1) Department of Neurology, Kanazawa University School of Medicine, Takaramachi, 920 Kanazawa City, Ishikawa, Japan;(2) Department of Internal Medicine, National Kanazawa Hospital, Kanazawa, Japan |
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| Abstract: | Summary The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly CD4+ T cells and the inflammatory cells in and around the muscle fibres were chiefly macrophages. Expression of major histocompatibility complex class I and II antigens was observed in the infiltrating cells and endothelial cells of the blood vessels. A small proportion of the infiltrating cells expressed interferon- . A possible role of the immune mechanism in the evolution of myositis is discussed. |
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| Keywords: | Myositis Toxoplasmosis Macrophages T lymphocytes Major histocompatibility complex |
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