| 饮食调整治疗大鼠非酒精性脂肪性肝炎 |
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| 引用本文： | 钟岚,刘菲,王军臣,袁琼英,徐文. 饮食调整治疗大鼠非酒精性脂肪性肝炎[J]. 国际消化病杂志, 2006, 26(3): 208-210 |
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| 作者姓名： | 钟岚 刘菲 王军臣 袁琼英 徐文 |
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| 作者单位： | 200120,同济大学附属上海市东方医院消化科;200120,同济大学附属上海市东方医院消化科;200120,同济大学附属上海市东方医院消化科;200120,同济大学附属上海市东方医院消化科;200120,同济大学附属上海市东方医院消化科 |
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| 基金项目： | 上海市卫生局青年基金资助项目(004y3) |
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| 摘 要： | 目的:观察单纯饮食改变治疗大鼠非酒精性脂肪性肝炎(NASH)的作用。方法:30只SD大鼠随机分为3组(每组n=10):正常组喂普通饲料;模型组喂高脂饲料;饮食治疗组在高脂饮食12周后恢复正常饲料喂养。16周后处死动物。结果:正常饮食能显著降低造模大鼠的体重、肝指数、转氨酶,还能改善肝脏脂肪变性和炎症坏死的程度。结论:单纯恢复正常饮食即可治疗大鼠NASH。
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| 关 键 词： | 非酒精性脂肪性肝炎 饮食治疗 实验研究 |
| 收稿时间： | 2006-03-31 |
| 修稿时间： | 2006-03-31 |
Therapeutic effect of diet change on non-alcoholic steatohepatitis in rats |
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| ZHONG Lan,LIU Fei,WANG Jun-chen,YUAN Qiong-ying,XU Wen. Therapeutic effect of diet change on non-alcoholic steatohepatitis in rats[J]. International Journal of Digestive Disease, 2006, 26(3): 208-210 |
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| Authors: | ZHONG Lan LIU Fei WANG Jun-chen YUAN Qiong-ying XU Wen |
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| Abstract: | Objective: To investigate the therapeutic effects of diet change on Non-alcoholic steatohepatitis(NASH) by means of rat model. Methods:Thirty Male SD rats were divided into three groups. The controlled group(n=10)were fed with normal diet;the NASH model group were fed with high-fat diet ; The diet therapy group were fed with high-fat diet for twelve weeks .then fed with normal diet. Sixteen weeks later, all rats were sacrificed. Results: The diet therapy group had a beneficial effect on lowing weight, liver index, serum aminotransferase activity. A significant improvement in some histological features such as steatosis and inflammation were also observed. Conclusion: Diet therapy is effective in ameliorating NASH in rats. |
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| Keywords: | Non-alcoholic steatohapatitis Diet therapy Experimental study |
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