| NBA的合成工艺改进 |
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| 引用本文： | 陈洪超 简锡贤. NBA的合成工艺改进[J]. 华西药学杂志, 1991, 6(2): 89-90 |
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| 作者姓名： | 陈洪超 简锡贤 |
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| 作者单位： | 华西医科大学药学院，华西医科大学药学院，华西医科大学药学院 |
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| 摘 要： | 利用KOH和相转移催化剂1~#或2~#,由已内酰胺和正-溴丁烷合成1-正丁基氮杂环庚烷-2-酮。实验证明KOH与己内酰胺的摩尔比为2,反应时间为2hr,和它们的摩尔比为2.5,反应时间1hr,收率都在85～89％。
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| 关 键 词： | NBA 合成工艺 相转移催化剂 KOH |
SYNTHESIS OF N-BUTYL-AZACYCLOHEPTAN-2-ONE |
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| Chen Hong Chao Jian Xi Xian Zhong Zhi Chen. SYNTHESIS OF N-BUTYL-AZACYCLOHEPTAN-2-ONE[J]. West China Journal of Pharmaceutical Sciences, 1991, 6(2): 89-90 |
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| Authors: | Chen Hong Chao Jian Xi Xian Zhong Zhi Chen |
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| Abstract: | 1-butyl-azacycloheptan-2-one is a better penetration enhancer, it was prepared by means of KOH and phase transfer Catalyst 1 Or 2. The operation is simple, having a short reaction time and good yields. The ratio of mol between KOH and caprolactam and reaction time were discussed. |
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| Keywords: | Vehicle Phase transfercatalyst accelerator |
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