内源性一氧化碳在慢性阻塞性肺疾病的变化

目的　探讨内源性一氧化碳 ( CO)在慢性阻塞性肺疾病 ( COPD)中的作用。方法　应用拜尔 85 5血气分析仪直接检测 30名 COPD急性发作期患者及 30名对照组动脉血一氧化碳血红蛋白 ( COHb)含量、p H、PO2 、PCO2 等指标 ,同时测定了各组的血浆一氧化氮 ( NO)水平。结果　 COPD与对照组 COHb分别为 :2 .0 6± 0 .5 3% ,0 .82± 0 .38% ;NO分别为 46.8± 1 5 .7,71 .2± 8.9μmol/L。两组比较 t值分别为1 0 .2和 7.4( P均 <0 .0 1 ) ,差异均有显著性 ,COPD患者血 COHb与血浆 NO水平呈显著负相关 ( r=-0 .5 73,P<0 .0 1 )。结论　内源性 CO是在 NO之外的又一个内源性介质参与 COPD的一系列病理生理过程 ,其生物学作用及其临床价值需进一步探讨。

Changes of Endogenous Carbon Monoxide in Patients with Chronic Obstructive Pulmonary Disease

Objective To investigate the changes of carbon monoxide (CO)in patients with chronic obstructive pulmonary disease(COPD).Methods Examined COHb,NO,pH,PO 2 and PCO 2 levels in arterial blood and NO levels in plasma of 30 COPD and 30 controls.Results COPD in acute attack stage had increased levels of COHb and decreased levels of NO in blood compared with control subjects (P<0.01),while PO 2 was significantlly lower and PCO 2 higher than those in the controls (P<0.01).The elevation of COHb in arterial blood negative correlated with elevated NO level in COPD.Conclusion Present data show that endogenously produced CO is increased during the course of COPD,which suggested that the role of CO in COPD might be worth further study.