| 双氢青蒿素、青蒿琥酯和蒿甲醚连续给药及伍用治疗小鼠血吸虫病效果观察 |
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| 引用本文： | 李洪军,汪伟,曲国立,戴建荣,陶永辉,李幼子,邢云天,魏剑英,梁幼生.双氢青蒿素、青蒿琥酯和蒿甲醚连续给药及伍用治疗小鼠血吸虫病效果观察[J].中国病原生物学杂志,2011(8). |
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| 作者姓名： | 李洪军 汪伟 曲国立 戴建荣 陶永辉 李幼子 邢云天 魏剑英 梁幼生 |
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| 作者单位： | 江苏省血吸虫病防治研究所卫生部寄生虫病预防与控制技术重点实验室江苏省寄生虫分子生物学重点实验室; |
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| 基金项目： | 国家科技支撑计划(No.2009BAI78B06); 江苏省卫生厅项目(No.X200911、X200912); 江苏省预防医学研究课题(No.Y201031) |
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| 摘 要： | 目的观察双氢青蒿素、青蒿琥酯和蒿甲醚连续给药或伍用治疗小鼠血吸虫病的效果,为日本血吸虫病病原学治疗提供药物配伍实验依据。方法采用腹部贴片感染法,每鼠感染日本血吸虫尾蚴40±1条,分别于感染后6~8 d(童虫期)和34~36 d(成虫期),以300 mg/kg双氢青蒿素、青蒿琥酯和蒿甲醚连续给药及3种药物等剂量配伍给药,在感染后50 d解剖小鼠,收集成虫,计算减虫率和减雌率。结果在感染后6~8 d,双氢青蒿素、青蒿琥酯、蒿甲醚连续3 d单独给药和3种药物等剂量配伍给药,小鼠减虫率为79.5%~86.0%;减雌率为79.4%~86.7%,差异均无统计学意义(P均>0.05);在感染后34~36 d给药,减虫率为73.8%~75.8%,减雌率为88.7%~93.1%,差异无统计学意义(P均>0.05)。结论双氢青蒿素、青蒿琥酯和蒿甲醚连续给药及伍用治疗小鼠血吸虫病效果无显著差异。
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| 关 键 词： | 血吸虫病 双氢青蒿素 青蒿琥酯 蒿甲醚 连续给药 伍用 |
Effects of dihydroartemisinin,artemether,and artesunate administered orally in multiple doses or in combination to treat mice with schistosomiasis |
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| LI Hong-jun,WANG Wei,QU Guo-li,DAI Jian-rong,TAO Yong-hui,LI You-zi,XING Yun-tian,WEI Jian-ying,LIANG You-sheng.Effects of dihydroartemisinin,artemether,and artesunate administered orally in multiple doses or in combination to treat mice with schistosomiasis[J].Journal of Pathogen Biology,2011(8). |
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| Authors: | LI Hong-jun WANG Wei QU Guo-li DAI Jian-rong TAO Yong-hui LI You-zi XING Yun-tian WEI Jian-ying LIANG You-sheng |
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| Institution: | LI Hong-jun,WANG Wei,QU Guo-li,DAI Jian-rong,TAO Yong-hui,LI You-zi,XING Yun-tian,WEI Jian-ying,LIANG You-sheng(Jiangsu Institute of Parasitic Diseases,Key Laboratory on Technology for Parasitic Disease Prevention and Control,Ministry of Health,Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites,Wuxi 214064,Jiangsu,China) |
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| Abstract: | |
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| Keywords: | Schistosomiasis dihydroartemisinin artesunate artemether continuous administration combination therapy |
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