| PD-L1与记忆性T细胞在肝囊型包虫病患者CD4~+T淋巴细胞中的表达及意义 |
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| 引用本文： | 巫姜,李涛,张志,董瑞强,周洋,金一帮,林仁勇,温浩. PD-L1与记忆性T细胞在肝囊型包虫病患者CD4~+T淋巴细胞中的表达及意义[J]. 中国病原生物学杂志, 2011, 0(12) |
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| 作者姓名： | 巫姜 李涛 张志 董瑞强 周洋 金一帮 林仁勇 温浩 |
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| 作者单位： | 新疆医科大学第一附属医院新疆重大疾病医学重点实验室-省部共建国家重点实验室培育基地新疆包虫病基础医学重点实验室;新疆医科大学第一附属医院消化血管外科中心;山西省忻州职业技术学院;石河子大学医学院; |
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| 基金项目： | 国家自然科学基金项目(No.30960342); 新疆维吾尔自治区高技术研究与发展计划项目(No.200810104); 新疆包虫病基础医学重点实验室开放课题(No.XJDX0202-2008-05,XJDX0202-2011-06) |
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| 摘 要： | 目的检测程序性死亡受体配体-1(PD-L1)及记忆性T细胞在肝囊型包虫病患者CD4+T淋巴细胞中的表达,探讨其在细粒棘球蚴感染免疫逃避中的作用。方法具有包虫活性的肝包虫病患者42例,健康对照20例,取血,分离PBMC,流式细胞术检测PD-L1(CD274+)、CD45RO+及CD4+CD45RO+CD274+细胞比例,并分析PD-L1与CD45RO的相关性。结果肝囊型包虫病患者PBMC中PD-L1、CD45RO+及CD4+CD45RO+CD274+细胞比例均显著高于健康对照组(P<0.05);肝囊型包虫病患者的PD-L1与CD45RO呈显著正相关(P<0.05),健康对照组二者无显著相关关系(P>0.05)。结论在肝囊型包虫病患者的免疫反应中,PD-L1可能通过记忆性T淋巴细胞发挥促进包虫免疫逃避的作用。
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| 关 键 词： | 细粒棘球蚴病 PD-L1 CD4 表达 流式细胞术 |
Expression of PD-L1 and memory T cells in CD4~+T lymphocytes of patients with liver cystic echinococcosis |
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| WU Jiang,,LI Tao,ZHANG Zhi,DONG Rui-qiang,ZHOU Yang,JIN Yi-bang,LIN Ren-yong,WEN Hao. Expression of PD-L1 and memory T cells in CD4~+T lymphocytes of patients with liver cystic echinococcosis[J]. Journal of Pathogen Biology, 2011, 0(12) |
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| Authors: | WU Jiang LI Tao ZHANG Zhi DONG Rui-qiang ZHOU Yang JIN Yi-bang LIN Ren-yong WEN Hao |
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| Affiliation: | WU Jiang1,2,LI Tao1,ZHANG Zhi3,DONG Rui-qiang4,ZHOU Yang1,JIN Yi-bang1,LIN Ren-yong1,WEN Hao1,2 (1.Base to Foster a State Key Lab for Major Disease Research in Xinjiang and Xinjiang Key Lab on Echinococcosis,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China,2.Gastrointestinal Vascular Surgery Center,3.Xinzhou Vocational and Technical College,Shanxi Province,4.Medical College of Shihezi University) |
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| Abstract: | Objectives To determine the expression of programmed death receptor ligand-1(PD-L1) and memory T cells in CD4+T lymphocytes of patients with a hydatid cyst in the liver and to explore the role of immune evasion in Echinococcus granulosus infection.Methods Subjects were 42 patients with active hepatic cystic echinococcosis and a control group of 20 healthy individuals.PBMCs were isolated and flow cytometry was used to detect the percentage of PD-L1(CD274+),CD45RO+,and CD4+CD45RO+CD274+ T cells.The correlatio... |
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| Keywords: | Cystic echinococcosis PD-L1 CD4 expression flow cytometry |
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