| 山东地区慢性HCV感染者病毒的基因型分布 |
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| 引用本文： | 张立新,安勇,张孝国,刘靓雯,于进红.山东地区慢性HCV感染者病毒的基因型分布[J].中国病原生物学杂志,2011(8). |
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| 作者姓名： | 张立新 安勇 张孝国 刘靓雯 于进红 |
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| 作者单位： | 济南市传染病医院; |
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| 摘 要： | 目的明确山东地区慢性丙型肝炎及丙肝肝硬化患者感染丙型肝炎病毒(HCV)的基因型分布,探讨HCV基因型与肝脏疾病严重程度及感染途径之间的关系。方法根据HCV 5′非编码区(NCR)设计基因芯片,对山东地区慢性HCV感染者(慢性丙型肝炎128例,丙肝肝硬化42例)应用基因芯片法检测HCV基因型,并对其中22份标本进行测序,比较慢性丙型肝炎、肝硬化病人HCV基因型分布以及不同途径感染的病HCV人基因型分布的差别。结果 168例患者标本可以分型,HCV基因型分别为:1b型106例,2a型48例,1a及3b型均为2例,1b+2a混合型9例,1a+1b混合型1例;对22例患者标本测序,1b型12例,2a型9例,3b型1例,与基因芯片法检测结果完全一致;肝硬化和慢性肝炎病人的HCV基因型分布差异无统计学意义(χ2=1.82,P>0.05),有输血史者和无输血史者HCV基因型分布差异无统计学意义(χ2=7.63,P>0.05)。结论山东地区HCV主要流行株是基因1b型,其次为2a型,同时有少量的1a、3b型以及混合感染,HCV基因型与疾病的进展及感染途径无关。
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| 关 键 词： | 肝炎病毒 丙型 基因型 感染途径 山东地区 |
Distribution of virus genotypes of patients with chronic hepatitis C infection in Shandong Province,China |
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| ZHANG Li-xin,AN Yong,ZHANG Xiao-guo,LIU Jing-wen,YU Jin-hong.Distribution of virus genotypes of patients with chronic hepatitis C infection in Shandong Province,China[J].Journal of Pathogen Biology,2011(8). |
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| Authors: | ZHANG Li-xin AN Yong ZHANG Xiao-guo LIU Jing-wen YU Jin-hong |
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| Institution: | ZHANG Li-xin,AN Yong,ZHANG Xiao-guo,LIU Jing-wen,YU Jin-hong(Jinan Infectious Disease Hospital,Jinan 250021,China) |
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| Abstract: | Objective To investigate the hepatitis C virus(HCV) genotypes of patients with chronic hepatitis C and cirrhosis in Shandong Province and study the relationship between the genotypes of HCV and the severity of liver disease and route of HCV infection.Methods Gene chips were designed based on the 5' non-cording region(NCR) of HCV.Serum samples from patients with chronic HCV infection(128 with chronic hepatitis and 42 with liver cirrhosis) were tested for HCV genotypes using a gene chip assay.Twenty-two of th... |
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| Keywords: | Hepatitis C virus genotype route of infection Shandong Province |
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