生泰王对小鼠应激能力及体内抗氧化酶活性的影响

目的:观察生泰王饮剂对小鼠应激能力和血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响.方法:取小鼠随机分为生泰王饮剂高、低剂量组和对照组,生泰王高、低剂量组分别ig生泰王饮剂5,2.5 g·kg-1·d-1；对照组ig等剂量的生理盐水,连续给药7d后行常压耐缺氧实验、小鼠游泳耐疲劳实验、耐寒冷；实验分为4组,生泰王高、低剂量组、对照运动组和对照非运动组,连续给药21 d测定血清丙二醛(MDA)含量、超氧化物歧化酶(SOD)活力的影响并比较生泰王饮剂组与对照组差异.结果:对照运动组血清MDA水平显著性升高,SOD活性显著下降,与对照非运动组比较差异有统计学意义(P＜0.01).生泰王饮剂不同剂量组均可显著性提高血清SOD活力,降低MDA水平,与对照运动组相比,有统计学意义(P ＜0.05,P＜0.01)；延长小鼠力竭游泳时间,提高耐疲劳能力,生泰王不同剂量组分别比对照组提高45.18％和37.80％:延长小鼠常压耐缺氧时间,提高抗耐缺氧能力；提高小鼠在低温环境下的耐寒冷能力,降低死亡率；与对照组相比,有统计学意义(P ＜0.05,P＜0.01).结论:生泰王饮剂可以提高小鼠的应激能力,具有良好的体内抗氧化作用,可以延缓衰老.

Effects of Shengtaiwang Potion on the Activity of Anti-stress and Antioxidase in Mice

Objective: To observe the effect of Shengtaiwang potion on the activity of anti-stress and superoxide dismutase (SOD), malondialdehyde (MDA) in blood serum, and then investigate its role in delaying senility and mechanism involved. Method: Mice were randomly divided into control group (saline), 5, 2.5 g·kg^-1·d^-1 groups of Shengtaiwang potion (oral administration). Then the tests of hypoxia resistance in nomal pressure, fatigue resistance (anti-tire swimming) and anti-chilling were performed. The content of MDA and activity of SOD in blood serum was also determined in each group, reapectively. Result: Compared with control group, Shengtaiwang potion could significantly increase the activity of SOD and decrease the concent of MDA in serum; and improve the ability of anti-hypoxia, anti-fatigue and anti-chilling, owing to extending the time of hypoxia resistance and anti-tire swimming in nomal pressure, decreasing the mortality in hypothermia, respectively. Conclusion: Shengtaiwang potion can improve the ability of anti-stress, had well anti-oxidation in vivo, and then delayed senility.