Bursts of miniature end-plate potentials can be released from localized regions of the frog motor nerve terminal |
| |
Authors: | Ira S. Cohen William Van Der Kloot Stuart B. Barton |
| |
Affiliation: | 1. Department of Physiology and Biophysics, Health Sciences Center, SUNY at Stony Brook, New York, N.Y. 11794, U.S.A.;2. University Laboratory of Physiology, Oxford OX1 3PT, U.K. |
| |
Abstract: | We examined spontaneous transmitter release by simultaneously recording from end-plates with both an intracellular electrode and a focal extracellular electrode. In normal Ringer's solution the focal releases appear to be a near random portion of the pooled output. But in elevated [Sr2+]out bursts of miniature end-plate potentials (m.e.p.p.s.) occur, and these can be localized at a portion of the presynaptic terminal. The bursts are not artifacts caused by the focal recording technique. In some conditions, sections of the nerve terminal can exhibit an enhanced probability of quantal release that persists for seconds.We occasionally observe extracellular events that must be generated by m.e.p.p.s. in adjacent fibers. |
| |
Keywords: | miniature end-plate potential neuromuscular junction quantal release frog strontium extracellular miniature end-plate potential |
本文献已被 ScienceDirect 等数据库收录! |