胶原贴敷料对面部轻度痤疮的屏障功能作用观察

目的评价胶原贴敷料对面部轻度痤疮患者面部屏障功能的作用，同时观察痤疮皮损、炎症后色素沉着的变化。方法对36例患有面部轻度痤疮的受试者，采用自身左右面部对比的方法，采用胶原贴敷料治疗。在治疗前、治疗1周和治疗4周对面部皮肤角质层含水量、经皮水分丢失、皮脂量、皮肤颜色进行测试；采用炎症性皮损和粉刺计数判定痤疮皮损改善情况。结果患者治疗侧面部皮肤角质层含水量显著升高（P〈0．05）；经皮水分丢失明显下降（P〈0．01），治疗侧发生皮肤红斑，粗糙和脱屑低于对照侧面部皮肤。治疗侧炎性丘疹数目减少，红斑指数下降，但与对照侧相比无统计学差异。所有受试者均未出现不良反应。结论胶原贴敷料单独使用可促进轻度痤疮患者的面部屏障功能的修复，同时对于炎症性皮损、皮肤红斑反应有一定的抑制作用。

Barrier function repairment of facial mild acne vulgaris with collagen dressing

Objective To evaluate the impact ofenllagen dressing on skin barrier function in patients with mild acne. Methods 36 patients with mild acne were enrolled in this randomized, self controlled, split-face study. The patients were asked to apply the collagen dressing on one side of the face randomly. The patients were measured by non-invasive measurements including water content in the stratum comeurn, transepidermal water Ioss（TEWL）, sebum excretion and skin color at baseline, 1-week and 4-week after treatment. The number of inflammatory papules and pimples was counted to analyze the efficacy. Results The water content in the stratum comeum increased obviously （P〈0.05） and TEWL decreased evidently on treated side （P 〈 0.01）, which illustrated that the collagen dressing could improve skin barrier function in ache patients .The treated side was less prone to experience erythema, roughness and peeling. The number of inflammatory papules decreased, so did the erythema index on the treated side, however, there wasn＇t statistical significance. No adverse event was reported during the study. Conclusions For patients with mild acne, applying collagen dressing alone could accelerate recovery of skin barrier. It would also inhibit with the inflammation.