血液流变性检测在冠心病心绞痛分型诊断中的价值

目的:探讨血液流变性改变对冠心病心绞痛发病机制及分型诊断的作用。方法:用全自动血液粘度仪测定稳定型心绞痛(SAP)46例、不稳定型心绞痛(UAP)86例、正常对照组40例的血液流变学指标。结果:SAP和UAP患者的全血高切粘度、全血低切粘度、血浆粘度、红细胞压积、全血高切还原粘度、全血低切还原粘度、血浆纤维蛋白原含量和红细胞聚集指数均高于对照组(P<0.01),且UAP组高于SAP组(P<0.01);SAP和UAP的红细胞变形指数均低于对照组(P<0.01),且UAP组低于SAP组(P<0.01)。结论:冠心病心绞痛患者存在血液流变性异常,UAP的异常程度更严重。血液流变学指标检测在冠心病心绞痛的分型诊断中有重要参考价值。

Value of Hemorheology in Angina Pectoris Classification

Objective: To investigate the pathogenesis of angina pectoris by hemorheology change and its value in classification of this disease. Method: The hemorheogical parameters of 46 cases of stable angina pectoris (SAP), 86 cases of unstable angina pectoris (UAP), and 40 controls were measured with an automated blood viscometer. Results: The whole blood viscosity in high and low shear rates, plasma viscosity, hematocrit, the whole blood reduction viscosity in high and low shear rates, plasma fibrinogen content, and aggregation index of RBC of the SAP and UAP patients were higher than those of the controls (P<0.01), of which the UAP patients were higher than the SAP patients (P<0.01). The deformation indexes of RBC of the SAP and UAP patients were lower than that of controls, of which the UAP patients was lower than the SAP patients (P<0.01).Conclusion: The angina pectoris patient has the abnormal hemorheology. It is more serious in unstable angina pectoris. The hemorheology index can be a valuable reference in angina pectoris classification.