| 喉癌组织RB基因突变及其与临床分期的关系 |
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| 引用本文： | 王斌全,陈彦球,温树信,王建明,皇甫辉,李育军. 喉癌组织RB基因突变及其与临床分期的关系[J]. 临床耳鼻咽喉头颈外科杂志, 2003, 17(2): 89-91 |
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| 作者姓名： | 王斌全 陈彦球 温树信 王建明 皇甫辉 李育军 |
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| 作者单位： | 山西医科大学第一医院耳鼻咽喉科,太原,030001 |
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| 摘 要： | 目的：探讨喉癌组织中RB基因突变及其与临床分期的关系。方法：用聚合酶链式反应和单链构象多态性（PCR-SSCP）对90例喉癌标本进行检测。结果：90例中，2例发生纯合性缺失，12例SSCP异常电泳，总突变率15.5%(14/90);Ⅰ-Ⅱ期喉癌RB基因突变5例（13.9%),Ⅲ-Ⅳ期RB基因突变9例（16.7%)，两者之间差异无显著性意义。结论：RB基因突变在喉癌的发生发展中起着一定的作用，RB基因突变与喉癌病程无关。
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| 关 键 词： | 喉肿瘤 聚合酶链反应 RB基因 |
| 文章编号： | 1001-1781(2003)02-0089-03 |
| 修稿时间： | 2002-05-18 |
Study of RB gene in carcinoma of larynx |
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| WANG Binquan CHEN Yanqiu WEN Shuxin WANG Jianming HUANGPU Hui LI Yujun. Study of RB gene in carcinoma of larynx[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2003, 17(2): 89-91 |
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| Authors: | WANG Binquan CHEN Yanqiu WEN Shuxin WANG Jianming HUANGPU Hui LI Yujun |
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| Affiliation: | Department of Otorhinolaryngology, First Clinical Hospital, Shanxi Medical University, Taiyuan 030001. |
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| Abstract: | OBJECTIVE: To probe the mutations of RB gene in laryngeal carcinoma, and the relation between it and the clinical phase. METHOD: The mutations were detected by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism). RESULT: In laryngeal carcinoma, the mutations were identified in 14(15.5%) of 90 samples, of which 2 were large deletion, 12 were abnormal in electrophoresis of SSCP. The mutations of I-II stage tumor were 5(13.9%), of III-IV were 9(16.7%), there wasn't a significant difference between them. CONCLUSION: RB gene mutation takes part in the development of laryngeal carcinoma. But there wasn't relation between RB gene mutation and the course of laryngeal carcinoma. |
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| Keywords: | Laryngeal neoplasms Polymerase chain reaction RB gene |
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