Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh |
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| Authors: | Gamble Mary V Liu Xinhua Ahsan Habibul Pilsner J Richard Ilievski Vesna Slavkovich Vesna Parvez Faruque Chen Yu Levy Diane Factor-Litvak Pam Graziano Joseph H |
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| Affiliation: | Departments of Environmental Health Sciences, Columbia University, New York, NY, USA. mvg7@columbia.edu |
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| Abstract: | BACKGROUND: Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent one-carbon metabolism; impaired methylation is associated with adverse health outcomes. Consequently, folate nutritional status may influence arsenic methylation and toxicity. OBJECTIVE: The objective of this study was to test the hypothesis that folic acid supplementation of arsenic-exposed adults would increase arsenic methylation. DESIGN: Two hundred adults in a rural region of Bangladesh, previously found to have low plasma concentrations of folate (
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