中西药联合治疗急性脑梗死疗效观察

目的:探讨奥扎格雷钠联合纳络酮、疏血通治疗急性脑梗死的临床疗效。方法:将110例急性脑梗死患者随机分为治疗组与对照组各55例,其中对照组给予中药疏血通注射液治疗,治疗组在此基础上加用西药奥扎格雷钠与盐酸纳络酮注射液治疗,分别于治疗前后对患者神经功能缺损情况(NHSS)和血液流变学指标进行检测,对比分析对照组与治疗组疗效。结果:①治疗组显效率为67.27%,总有效率为90.91%,对照组显效率为47.27%,总有效率为85.45%,两组间差异有统计学意义(P<0.01或P<0.05),所有患者均无明显不良反应;②经过治疗,治疗组患者NHSS评分从(27.18±6.55)降至(14.49±3.32),对照组患者从(28.32±6.14)降至(19.93±3.74),治疗组NHSS评分下降幅度大于对照组(P<0.05);③治疗后,所有患者血液粘稠度、红细胞压积、纤维蛋白原水平和血小板凝集率均明显下降(P<0.01或P<0.05),且治疗组各血液流变学指标改善优于对照组(P<0.01或P<0.05)。结论:中西药联合治疗急性脑梗死疗效确切,值得进一步推广应用。

Clinical Study on Acute Cerebral Infraction Patients Treated by Combination of Chinese Traditional and Western Medicine

Objective：To explore the clinical effects of Chinese traditional combined with Western medicine on patients with acute cerebral infarction（ACI）.Methods：110 patients with ACI were randomLy divided into treatment group and control group,with 55 cases respectively in each group.The control group was treated with Shuxuetong injection,and the treatment group was added with sodium ozagrel and naloxone injection.The scores of NHSS and hemorheology parameters were detected before and after treatment,and the therapeutic effect was comparatively analyzed between the two groups.Results：①The effectual rate and total effective rate were respectively 67.27% and 90.91% in treatment group,significantly higher than 47.27% and 85.45% in control group（P〈0.01orP〈0.05）,and there was no adverse reactions to drug in all patients.② After treatment,NHSS decreased from 27.18±6.55 to 14.49±3.32 in treatment group,from 28.32±6.14 to 19.93±3.74 in control group,and the decrease was more prominent in treatment group than the control group（P〈0.05）.③ The blood viscosity,hematocrit,levels of fibrinogen and platelet aggregation significantly decreased in all patients after treatment（P〈0.01 or P〈0.05）,especially in the treatment group（P〈0.01 or P〈0.05）.Conclusion：Conclusion： Combination of Chinese traditional and Western medicine is effective in treating acute cerebral infarction,thus worth being popularized in clinical treatment.