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The EMT signaling pathways in endometrial carcinoma |
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| Authors: | Eva Colas Nuria Pedrola Laura Devis Tug?e Ertekin Irene Campoy Elena Martínez Marta Llauradó Marina Rigau Mireia Olivan Marta Garcia Silvia Cabrera Antonio Gil-Moreno Jordi Xercavins Josep Castellvi Angel Garcia Santiago Ramon y Cajal Gema Moreno-Bueno Xavier Dolcet Francesc Alameda Jose Palacios Jaime Prat Andreas Doll Xavier Matias-Guiu Miguel Abal Jaume Reventos |
| Affiliation: | 1. Biomedical Research Unit, Vall d??Hebron Research Institute and University Hospital, Barcelona, Spain 2. Universitat Aut??noma de Barcelona, Barcelona, Spain 3. Servei de Ginecologia, Hospital Vall d??Hebron, Barcelona, Spain 4. Servei de Patologia, Hospital Vall d??Hebron, Barcelona, Spain 5. Departamento de Bioqu??mica-IIB CSIC-UAM, IdiPAZ and Fundaci??n MD Anderson Internacional, Madrid, Spain 9. Servei de Patologia, Hospital Arnau de Vilanova, Lleida, Spain 6. Servei de Patologia, Hospital del Mar, Barcelona, Spain 7. Servicio de Patolog??a, Hospital Virgen del Roc??o, Sevilla, Spain 8. Servei de Patologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain 10. Complejo Hospitalario de Santiago de Compostela, Santiago de Compostela, Spain 11. Department de Ci??ncies B??siques, Universitat Internacional de Catalunya, Barcelona, Spain |
| Abstract: | Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGF??, ETV5 and microRNAs are deeply related to the EMT process in EC. |
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