帕瑞昔布与氟比洛芬酯预防喉罩全麻术后不良反应的观察 |
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引用本文: | 朱丹,吕黄伟*. 帕瑞昔布与氟比洛芬酯预防喉罩全麻术后不良反应的观察[J]. 中国血液流变学杂志, 2012, 0(3): 444-446 |
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作者姓名: | 朱丹 吕黄伟* |
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作者单位: | 中国医科大学附属第一医院麻醉科,辽宁沈阳110001 |
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摘 要: | 目的对比研究帕瑞昔布和氟比洛芬酯预防喉罩全麻术后咽痛、躁动等不良反应。方法采用双盲、随机对照试验设计。选择76例骨科择期手术患者,随机分为3组,A组为对照组,患者25例,于诱导前给予生理盐水5mL静推;B组患者27例,于诱导前氟比洛芬酯1mg·kg-1静推;C组患者24例,于诱导前帕瑞昔布40mg静推。比较各组间上述时间点(T0、T1、T2)的MAP、HR波动情况及术后咽痛、躁动等不良反应的发生情况。结果各组间患者年龄、性别、体重、麻醉时间、舒芬太尼用量等差异均无统计学意义(P〉0.05)。在插管期,B组、C组的MAP、HR波动明显低于A组(P〈0.05);在拔管期,B组与C组的血流动力学波动及减少术后咽痛的发生明显优于A组(P〈0.05),但C组血流动力学及术后咽痛不良反应发生明显低于B组(P〈0.05)。结论诱导前静注帕瑞昔布40mg有利于喉罩全麻手术患者插管与拔管期血流动力学平稳,并可有效预防术后咽痛等不良反应的发生。
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关 键 词: | 帕瑞昔布 氟比洛芬酯 喉罩 术后咽喉痛 |
The Effects of Flurbiprofen and Parecoxib on Preventing Postoperative Side Effects in Laryngeal Mask Airway General Anesthesia |
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Affiliation: | ZHU Dan, L V Huang-wei (Department of Anesthesiology,the First Affiliated Hospital,China Medical University, Shenyang 110001,China) |
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Abstract: | Objective To compare the effects of flurbiprofen and parecoxib on preventing postoperative sore throat and restlessness in laryngeal mask airway general anestheaia.Methods Seventy-six patients undergoing selective operation of orthopedics with general anesthesia were randomly assigned to three groups.Group A(control group) was injected normal saline 10mL at 30min before induction;group B was injected flurbiprofen 1mg·kg-1 at 30min before induction;group C was injected parecoxib 40mg at 30min before induction.Compare the fluctuation of MAP, HR at the time of T0,T1,T2,and the side effects among the 3 groups.Results There is no statistic difference of age,sex,time of the operation,and the dosage of sulfentanyl among the groups(P 〉 0.05). The hemodynamic fluctuation in group B and group C are apparently lower than group A during intubation.The hemodynamic fluctuation and the incidence of postoperative throatache in group B and group C are apparently lower than group A during extubation.There is statistic difference between the groups(P 〈 0.05).But there is statistic difference between group B and group C during extubation.Conclusion Parecoxib axetil reduces hemodynamic fluctuation and the incidence of postoperative throatache in operations of orthopedics. |
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Keywords: | parecoxib flurbiprofen laryngeal mask airway postoperative throatache |
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