| 参仙升脉口服液对缓慢性心律失常大鼠缝隙连接蛋白Cx45的影响 |
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| 引用本文： | 侯平,刘宁,马贤德. 参仙升脉口服液对缓慢性心律失常大鼠缝隙连接蛋白Cx45的影响[J]. 中国心血管病研究杂志, 2012, 10(11): 865-866,880 |
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| 作者姓名： | 侯平 刘宁 马贤德 |
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| 作者单位： | 侯平 (辽宁中医药大学附属医院心内二科,沈阳市,110032) ； 刘宁 (辽宁中医药大学附属医院心内二科,沈阳市,110032) ； 马贤德 (辽宁中医药大学实验中心) ； |
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| 基金项目： | 辽宁省科学技术计划项目,辽宁省医学高峰建设项目,沈阳市科技计划项目 |
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| 摘 要： | 目的观察参仙升脉口服液对缓慢性心律失常大鼠缝隙连接蛋白Cx45的影响，探讨其治疗缓慢性心律失常的机制。方法用普萘洛尔制备缓慢性心律失常大鼠模型，观察参仙升脉口服液对缓慢性心律失常大鼠缝隙连接蛋白Cx45的影响。结果治疗组大鼠心率比模型组大鼠心率明显提高（P〈0．01），大鼠心肌组织缝隙连接蛋白cx45的表达比模型组明显增高（P〈0．01）。结论参仙升脉口服液可明显提高缓慢性心律失常大鼠缝隙连接蛋白Cx45的表达，这可能是其治疗缓慢性心律失常的机制之一。
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| 关 键 词： | 参仙升脉口服液 缓慢心律失常 缝隙连接蛋白Cx45 |
The impact of Shenxian shengmai oral solution on gap joint protein Cx45 of chronic cardiac arrhythmias rats |
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| HOU Ping%LIU Ning%MA Xian-de. The impact of Shenxian shengmai oral solution on gap joint protein Cx45 of chronic cardiac arrhythmias rats[J]. Chinese Journal of Cardiovascular Review, 2012, 10(11): 865-866,880 |
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| Authors: | HOU Ping%LIU Ning%MA Xian-de |
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| Affiliation: | . (Department of Cardiovasology 2, the Affiliated Hospital of Liaoning Uni-versity of TCM, Shenyang 110032, China) |
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| Abstract: | Objective To observe the impacts of Shenxian shengmai oral solution on gap joint protein Cx45 of bradycardia arrhythmias rats and to explore the possible mechanisms. Methods Observing the impact of Shenxian shengmai oral solution on gap joint protein Cx45 in bradycardia arrhythmias rats, which were induced by propranolol. Results The heart rate of rats and expression of gap joint protein Cx45 in treatment group was signif-icantly increased than the model group（P〈0.01 ）. Conclusion As compared with model group, the expression of gap joint protein Cx45 was significantly improved in the Shenxian shengmai oral solution group with statistical dif-ference, and it may be one of mechanism to treat bradycardia arrhythmias |
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| Keywords: | Shenxian shengmai oral solution Bradycardia arrhythmias Cx45 |
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