白质疏松对脑梗死患者认知功能的影响

目的探讨白质疏松对脑梗死患者认知功能的影响。方法采用MMSE量表评分追踪观察95例脑梗死患者，其中认知障碍组27例，无认知障碍组68例。结果经Logistic回归发现白质疏松（OR=3．444．95％CI=1．137-10．425]）和脑梗死史（OR=3．254，95％CI=1．180-8．975]）是认知障碍的独立危险因素。发病初期白质疏松组MMSE评分明显低于非白质疏松组，在发病1个月及3个月时的MMSE评分差值比较无显著差异，而在6个月及以后的评分中2组评分差值存在差异，白质疏松组的MMSE评分差值明显小于非白质疏松组，且白质疏松组MMSE评分下降。结论白质疏松和脑梗死史是脑梗死患者认知障碍的独立危险因素；白质疏松在脑梗死后会加重患者的认知障碍。

The effect of ischemia-related leukoaraiosis on cognitive function of stroke patients

Objective To investigate the effect of leukoaraiosis on cognitive function of stroke patients. Methods We observed 95 patients with acute cerebral infarction. They are divided into two groups. 27 patients had cognitive impairment and 68 patients had not it by using MMSE grading tables. Results In the multivariate logistic regression analysis, leukoaraiosis odds ratio （OR） = 3. 444,95 % confidence interval （CI = 1. 137 - 10. 425）] and history of stroke （OR = 3. 254,95%CI = 1. 180 - 8. 975） were the independent factors of cognitive impairment. MMSE scores in leukoaraiosis group was much lower than the control during the early stage. At the first and third month difference was not significant, but after the sixth month significant difference was found in two groups,and MMSE scores in leukoaraiosis group decreased. Conclusions Leukoaraiosis and history of stroke are the independent risk factors of cognitive impairment. Leukoaraiosis may aggraviate cognitive impairment after stroke.