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Short‐term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47phox subunit in monocytes from type 2 diabetes patients |
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| Authors: | Guillaume Vaquer Richard Magous Gérard Cros Anne Wojtusciszyn Eric Renard Hughes Chevassus Pierre Petit Anne‐Dominique Lajoix Catherine Oiry |
| Affiliation: | 1. Center of Pharmacology and Innovation in Diabetes, University Montpellier I, CNRS FRE 3400, , 34093 Montpellier, France;2. Department of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, CIC INSERM 1001, , 34090 Montpellier, France |
| Abstract: | Hyperglycemia is a well‐known inducing factor of oxidative stress through activation of NADPH oxidase. In addition to its plasma glucose lowering effect, insulin may also have antioxidant activity and was shown to downregulate NADPH oxidase expression in vitro. In this study, we show that a short‐term (3‐day) intravenous insulin infusion in patients with type 2 diabetes induces normalization of both glycemia and mRNA expression of circulating monocyte p47phox subunit. |
| Keywords: | diabetes insulin monocytes NADPH oxidase |