Safety in the Use of Dexmedetomidine (Precedex) for Deep Brain Stimulation Surgery: Our Experience in 23 Randomized Patients |
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| Authors: | Marco Sassi MD Edvin Zekaj MD Alessandra Grotta Alberto Pollini MD Armando Pellanda MD Massimo Borroni MD Claudio Pacchetti MD Claudia Menghetti MD Mauro Porta MD Domenico Servello MD |
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| Affiliation: | 1. Functional Neurosurgical Unit, IRCCS Galeazzi, Milan, Italy;2. Department of Statistics, University of Milano‐Bicocca, Milan, Italy;3. Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia, Italy |
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| Abstract: | Objective: Evaluation of safety and efficacy of dexmedetomidine in deep brain stimulation (DBS) surgery. Materials and Methods: A cohort of 23 patients, candidates for DBS for Parkinson's disease, Tourette syndrome, or obsessive‐compulsive disorder, was randomized in two groups: dexmedetomidine group and control group. Standard anesthesiologic parameters were recorded and analyzed, together with the need for other medications. A ten‐degree scale (visual analog scale) assessing patient discomfort during DBS also was recorded at the end of surgery. Results: The results demonstrated good stability of intraoperative monitoring: no respiratory depression and good overall cooperation with the neurologist, while no side‐effects were recorded. Conclusions: Our conclusion is that dexmedetomidine should be considered as a valuable option for sedation in poorly collaborating patients undergoing DBS surgery. |
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| Keywords: | anesthesiology deep brain stimulation dexmedetomidine safety sedation |
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