| THE CHARACTERIZATION OF MYOSIN LIGHT CHAIN PHOSPHORYLATION BY THE CONSTITUTIVELY ACTIVE FRAGMENT OF MLCK |
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| 作者姓名： | 杨静娴 王晓明 唐泽耀 陈华 戴淑芳 林原 |
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| 作者单位： | Department of Pharmacology，Dalian Medical Univeraity，Dalian116027，Department of Pharmacology，Dalian Medical Univeraity，Dalian116027，Department of Pharmacology，Dalian Medical Univeraity，Dalian116027，Department of Pharmacology，Dalian Medical Univeraity，Dalian116027，Department of Pharmacology，Dalian Medical Univeraity，Dalian116027，Department of Pharmacology，Dalian Medical Univeraity，Dalian116027 |
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| 基金项目： | ThisworkwassupportedbythegrantsofNationalNaturalScienceFoundationofChina(No.30070203). |
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| 摘 要： | INTRODUCTIONSmoothmusclecontractionisactivatedprimarilybytheCa2+-calmodulin(CaM)dependentphosphory-lationofmyosinlightchains(CDPM)bymyosinlightchainkinase(MLCK).ThephosphorylationcanbesimplydescribedasthattheinteractionofCa2+withCaMinducesaconformationalchangeofMLCKandresultsinactivationofMLCK,andtheactivatedML-CKcatalyzesphosphorylationofmyosinlightchain(MLC).ThephosphorylationofMLCstimulatesmyosinMg2+-ATPaseactivityandtriggerscyclingofmyosincross-bridgesalongactinfilaments…
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THE CHARACTERIZATION OF MYOSIN LIGHT CHAIN PHOSPHORYLATION BY THE CONSTITUTIVELY ACTIVE FRAGMENT OF MLCK |
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| Yang Jingxian,Wang Xiaoming,Tang Zeyao,Chen Hua,Dai Shufangand Lin Yuan.THE CHARACTERIZATION OF MYOSIN LIGHT CHAIN PHOSPHORYLATION BY THE CONSTITUTIVELY ACTIVE FRAGMENT OF MLCK[J].Chinese Medical Sciences Journal,2003,18(4). |
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| Authors: | Yang Jingxian Wang Xiaoming Tang Zeyao Chen Hua Dai Shufangand Lin Yuan |
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| Institution: | Yang Jingxian,Wang Xiaoming,Tang Zeyao,Chen Hua,Dai Shufangand Lin Yuan Department of Pharmacology,Dalian Medical Univeraity,Dalian116027 |
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| Abstract: | |
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| Keywords: | proteolysis MLCKF phosphorylation Mg 2+ -ATPase activity |
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