| PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO |
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| 作者姓名： | 桂鸣 Lu-YangWang |
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| 作者单位： | Department of Cardardiology，the First Affiliated Hospital，Nanjing Medical University，Nanjing 210029，The Program in Brain & Behavior and Division of Neurology，The Hospital for Sick Children and Department of Physiology，University of Toronto，555 University Avenue，Toronto，Ontario，Canada M5G IX8 |
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| 基金项目： | This work was supported by an operaing grant and a scholarship from the Medical Research Council of Canada(MRC)and by a start-up fund from the Hospital for Sick Children Research Institute to L,Y.W. |
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| 摘 要： | Objective. To investigate the properties of voltage-gated sodium (Na+) channels in developing auditory neurons during early postnatal stages in the mammalian central nervous system.Methods. Using the whole-cell voltage-clamp technique, we have studied changes in the electrophysi-ological properties of Na+ channels in the principal neurons of the medial nucleus of the trapezoid body (MNTB).Results. We found that MNTB neurons already express functional Na+ channels at postnatal day 1 (P1), and that channel density begins to increase at P5 when the neurons receive synaptic innervation and reach its maximum (~3 fold) at P11 when functional hearing onsets. These changes were paralleled by an age-dependent acceleration in both inactivation and recovery from inactivation. In contrast, there was very little alteration in the voltage-dependence of inactivation.Conclusion. These profound changes in the properties of voltage-gated Na+ channels may increase the excitability of MNTB neurons and enhance their phase-l
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PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO |
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| Gui Ming and Lu-Yang Wang.PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO[J].Chinese Medical Sciences Journal,2003,18(2):67-74. |
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| Authors: | Gui Ming and Lu-Yang Wang |
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| Institution: | Department of Cardiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029. |
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| Abstract: | Objective. To investigate the properties of voltage-gated sodium (Na+) channels in developing auditory neurons during early postnatal stages in the mammalian central nervous system.
Methods. Using the whole-cell voltage-clamp technique, we have studied changes in the electrophysi-ological properties of Na+ channels in the principal neurons of the medial nucleus of the trapezoid body (MNTB).
Results. We found that MNTB neurons already express functional Na+ channels at postnatal day 1 (P1), and that channel density begins to increase at P5 when the neurons receive synaptic innervation and reach its maximum (~3 fold) at P11 when functional hearing onsets. These changes were paralleled by an age-dependent acceleration in both inactivation and recovery from inactivation. In contrast, there was very little alteration in the voltage-dependence of inactivation.
Conclusion. These profound changes in the properties of voltage-gated Na+ channels may increase the excitability of MNTB neurons and enhance their phase-locking fidelity and capacity during high-frequency synaptic transmission. |
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| Keywords: | voltage-gated sodium channels auditory neurons development |
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